Immunotherapy in India
Cancer is a disease characterized by the uncontrolled growth and spread of abnormal cells. These cells can invade and destroy healthy tissues, leading to serious health complications. Indian statistics reveal:
- Around 1.3 million people receive a cancer diagnosis each year.
- 1 out of every 10 Indians will experience cancer at some point in their lives
Dr. Sandeep Nayak, a seasoned surgical oncologist in India, says:
“The immune system plays a crucial role in preventing cancer initiation, progression, and metastasis. But, tumors can evade immune detection. Luckily, immunotherapy treatment in India has emerged as a groundbreaking approach to combat cancer. It offers new hope to patients by harnessing the power of the body’s immune system to fight cancer.”
Overview of Immunotherapy
Immunotherapy differs from traditional therapies which target cancer cells. Immunotherapy boosts the immune system’s ability to identify and destroy malignant cells.
It includes both active and passive approaches:
Active immunology directs the body’s immune cells to recognize, attack, and destroy cancer cells. Examples include anti-cancer vaccines.
Passive immunotherapy facilitates and enhances the body’s existing immune response. Examples include checkpoint inhibitors.
Passive immunotherapy, which involves manipulating immune checkpoints, is the most successful approach. It works by turning off the immune response after T cells have killed cancer cells to protect healthy cells. Immune checkpoint inhibitors stop this off signal, allowing T cells to keep fighting cancer.
Are you or a loved one seeking the latest advancements in cancer treatments? Don’t hesitate to consult a cancer specialist. Early detection and personalized treatment plans can significantly impact your journey toward well-being.
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Cancer Types Responsive to Immunotherapy
Diagnosis of Thyroid Tumor in Bangalore
Bladder Cancer:
Immunotherapy has shown efficacy, particularly in advanced or metastatic cases.
Brain Cancer:
Breast Cancer:
Cervical Cancer:
Immunotherapy, including checkpoint inhibitors, is being investigated as a potential treatment for advanced cervical cancer.
Colorectal Cancer:
Medical experts are increasingly using immunotherapy in colorectal cancer. It is particularly helpful in cases with specific genetic mutations.
Esophageal Cancer:
Doctors are exploring immunotherapy as a treatment option for esophageal cancer, especially in combination with other therapies.
Head and Neck Cancer:
Immunotherapy, including checkpoint inhibitors, has shown promise in treating specific head and neck cancers.
Kidney Cancer:
Immunotherapy has become a standard treatment for advanced or metastatic kidney cancer.
Lung Cancer:
Leukemia:
Liver Cancer:
Cancer specialists are studying immunotherapy as a potential treatment for liver cancer, particularly in combination with other therapies.
Lymphoma:
Immunotherapy Treatment Process
Adoptive Cell Therapy (ACT)
ACT involves collecting and using the patient’s immune cells to treat their cancer. The most prominent type of ACT is CAR-T cell therapy.
The process begins by extracting T cells from the patient’s blood. These T cells are then modified in a lab to have chimeric antigen receptors (CARs) that detect specific proteins in cancer cells. The modified T cells are multiplied and then infused back into the patient to target and destroy the cancer cells.
Cancer Vaccines
Cancer vaccines aim to stimulate an immune response against specific cancer antigens. These vaccines can be:
- Preventive, like the HPV vaccine that prevents cervical cancer
- Therapeutic, designed to treat existing cancers
Therapeutic cancer vaccines introduce antigens associated with cancer cells into the body. They stimulate the immune system to attack cells expressing these antigens.
Immune Checkpoint Inhibitors
Immune checkpoint inhibitors block proteins that prevent the immune system from attacking cancer cells. These proteins, such as PD-1, PD-L1, and CTLA-4, act as brakes on the immune system. By inhibiting these checkpoints, the immune system can more effectively recognize and destroy cancer cells.
Immunomodulators
Immunomodulators are agents that modify the immune system’s response to cancer. They can enhance or suppress immune functions to improve the body’s ability to fight cancer.
Monoclonal Antibodies
Monoclonal antibodies are lab-made molecules that can bind to specific targets on cancer cells. The ability to target a particular antigen on cancer cells makes this approach highly precise. These antibodies can:
- mark cancer cells for destruction by the immune system
- block growth signals
- deliver radiation or chemotherapy directly to cancer cells
- recruit immune cells to attack cancer cells
Would you like to explore the options of immunotherapy in India for cancer? Reach out to an immunotherapy specialist to discuss the best treatment approach for you.
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After completing immunotherapy, patients often wonder what the next steps are. It’s not just about monitoring the disease but also about ensuring well-being. Here’s where post-treatment care becomes vital.
Post Immunotherapy care
Post-immunotherapy care ensures the best possible recovery and long-term health outcomes. It includes:
Regular Monitoring
Regular monitoring involves routine blood tests, imaging studies, and physical examinations. It helps identify signs of disease progression or recurrence and allows for timely intervention.
Managing Side Effects
Immunotherapy can sometimes lead to side effects that persist even after treatment has ended. Your healthcare team will provide strategies and medications to help control these symptoms.
Healthy Lifestyle
Embracing a healthy lifestyle can significantly impact recovery and well-being. This includes a balanced diet, regular physical activity, adequate sleep, and stress management techniques.
Emotional Support
Psychological and emotional support is also a critical part of post-treatment care. Consider joining support groups or seeking counseling to help cope with the emotional aspects of your cancer journey.
Specialist Referral
The doctor may refer patients to specialists to manage specific side effects or complications related to immunotherapy. For instance,
- you may need to consult a cardiologist for heart-related side effects
- a dermatologist may be the right approach for severe skin reactions
Multidisciplinary care involving various specialists ensures comprehensive patient health management during and after immunotherapy.
Conclusion
Frequently Asked Questions
What are the side effects of immunotherapy?
The side effects of immunotherapy, particularly from treatment with checkpoint inhibitors, can vary in severity and affect different body parts. Commonly affected organs and tissues include:
Skin: Skin-related side effects are common.
Colon: Gastrointestinal issues such as colitis can occur.
Lungs: Pneumonitis is a possible side effect.
Liver: Hepatitis may develop.
Endocrine system: Endocrine disorders, such as thyroid dysfunction, can arise.
These side effects appear within weeks to a few months of starting treatment. They may persist or first appear even after treatment has finished. Most side effects are mild and reversible if reported and addressed early.
How will immunotherapy-related side effects be managed?
Management of immunotherapy-related side effects follows specific principles depending on the severity of the symptoms:
Mild side effects (Grade 1 or Grade 2):
- Doctors treat symptoms without disturbing or stopping the treatment.
- Regular monitoring, including blood tests, is conducted to detect early signs of side effects.
Persisting Grade 2 symptoms:
- Patients may need to miss one or multiple treatment doses.
- Doctors provide additional treatments for the symptoms as needed.
Severe side effects (Grade 3 or Grade 4):
- The doctor will stop the treatment.
- The medical team will arrange for a referral to a specialist, such as a dermatologist, for severe skin symptoms to provide targeted care.
Early detection and appropriate management are crucial. They can help reverse the side effects and prevent complications.
Will the doctor adjust the immunotherapy regimen based on the patient's response?
Based on the patient’s response and side effects, adjustments to the immunotherapy could include:
- changing the dosage
- switching to a different type of immunotherapy
- combining it with other treatments
Personalized adjustments ensure that the patient receives the most effective treatment.
What is the immunotherapy cost in India?
The cost can fluctuate due to various factors, including:
- The type of cancer
- The specific immunotherapy drugs used
- The duration of treatment for each session
Please get in touch with a certified immunotherapy doctor in India for an approximate cost based on your condition.